Of these ten, there are six level packs and four character packs based on Marvel Cinematic Universe films, superhero teams, and time variant heroes:

On 6 October, ten DLC packs were announced for the game. The ability to manipulate time is allowed to players directly from the new open world of Chronopolis, which is a myriad of 17 different Marvel locations (consisting of a variation of Ancient Egypt, an apocalyptic Asgard, Attilan, Hala, the Hydra Empire, K'un-L'un, Knowhere, Lemuria, Man-Thing's Swamp, Manhattan, an alternate version of Medieval England, a Marvel Noir version of New York City called Manhattan Noir, Nueva York, a variation of the Old West, Sakaar, Wakanda, and Xandar) linked through time and space and surrounding Kang the Conqueror's Citadel. Despite this, many of these characters appeared in the first game. These characters included: the Fantastic Four, the X-Men (and by extension, all mutants, including Deadpool), Namor the Sub-Mariner, and others. The game was also released during the infamous 'Fox embargo', an unofficial block on characters that Marvel Studios did not own the cinematic rights to. 2) and move time forward for him to become his adult version, and Spider-Man can go both ways with his Noir and 2099 counterparts. For instance, they can take Baby Groot (from the Guardians of the Galaxy Vol. Using the ability to manipulate time, the players can change the look and abilities of certain characters.

While some characters are just based on the comic books, others have their visuals taken from the Marvel Cinematic Universe, such as the Guardians of the Galaxy, Doctor Strange, and Ant-Man. In addition, the game also features variations of sundry characters, like Iron Duck (who is merely Howard the Duck wearing the Iron Man's armor) and Carnom (a fusion of the Venom symbiote and the Carnage symbiote that is exclusive to the game). The game also features characters from different time periods and realities over the Marvel Universe, which includes Spider-Gwen, a cowboy version of Captain America, a medieval counterpart of Hulk, and many others.

For example, Star-Lord is capable of flight, Black Panther can activate claw switches, and Spider-Man can swing on his webs, crawl on walls and use his spider-sense to detect hidden objects.

Much like the two previous Lego Marvel games, the players are able to take control of a roster of iconic characters from the Marvel Universe, each with their own unique abilities. The game also introduces a new four-player competitive Super Hero battle mode, allowing players to fight each other cooperatively in battle arenas. The game features a similar gameplay to its predecessors and other Lego video games, alternating between various action-adventure sequences and puzzle-solving scenarios. Lego Marvel Super Heroes 2 is an action-adventure game played from a third-person perspective.

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